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The first Benos Lab Newsletter!

After nearly 20 years since its beginning our Lab put together its first NewsLetter!  The last 2 years were challenging and full of events. From the BLM movement to elections and let’s not forget this “other thing”. The Lab stayed isolated but still productive. This first Newsletter serves as…

Benos Lab receives NIH funding to develop interpretable graphical models

The Benos Lab received an R01 grant from NHLBI-NIH to develop interpretable probabilistic graphical models for multi-modal datasets. The methods will be used to identify factors causally linked to the progression of chronic obstructive pulmonary disease (COPD). COPD is the 3rd leading cause of death worldwide [1]. In 2019,…

Benos Lab receives NIH funding to study COPD subtypes

The Benos Lab received an R01 grant from NHLBI-NIH to develop machine learning methods to identify and study chronic obstructive pulmonary disease (COPD) subtypes. COPD is the 3rd leading cause of death worldwide [1]. In 2019, WHO estimated that 3.23 million people died for COPD [2]. More than 140,000…

Haopu publishes in JCI Insight

Congratulations to Haopu for the acceptance by JCI Insight of his sixth paper! The paper, “Plasma 1,3-beta-D-glucan levels predict adverse clinical outcomes in critical illness“, analyzed data from 453 mechanically-ventilated patients and found a new biomarker whose baseline levels are predictive of fewer ventilator-free days and worse 30-day survival. This is a collaboration…

Khaled publishes in Cell Reports

Congratulations to Khaled for the acceptance by Cell Reports of a paper he co-authored. The paper, “Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors“, investigates the gene networks that drive hepatic cell development.  This is a collaboration with the lab of Paul…

Congratulations to Robert for his T15 NIH fellowship

Robert Gregg, a postdoctoral fellow in our group, was awarded an NIH-NLM T15 Postdoctoral Scholarship from the Department of Biomedical Informatics, University of Pittsburgh School of Medicine.  This is a recognition of the high-quality work of Robert in the field of computational biology and machine…

Minxue publishes in Nature Communications

Congratulations to Minxue for the acceptance of the paper he co-authored to Nature Communications. The paper is entitled “Myofibroblast transcriptome indicates SFRP2+ fibroblast progenitors in systemic sclerosis skin” and presents the results of single cell RNA-seq analysis, which indicate key events that transform fibroblasts to myofibroblasts. Congratulations Minxue! Paper availability:…

Congratulations to Minxue for the successful defense of his thesis proposal

Minxue successfully defended his thesis proposal.  The title of his thesis is “Graphical methods for single sample network analysis with applications to aging and chronic lung diseases“.  His thesis committee consists of Jianhua Xing (chair), Carl Kingsford (CMU), Yu-Chih Chen.  Congratulations Minxue!  …

Vineet publishes a first author paper in Pediatric Crit Care Med

Congratulations to Vineet for the acceptance of his paper “Neurological Complications Acquired during Pediatric Critical Illness:  Exploratory ‘Mixed Graphical Modeling’ Analysis using Serum Biomarker Levels” in the Pediatric Crit Care Med.  This study investigates the factors affecting the development of neurological disorders in the ICU, using mixed graphical models. Congratulations…