Congratulations to our group member (now alumnus), Daniel Yuan for the acceptance of his first author paper in the European Journal of Cancer. His paper is entitled “Immune cell transcriptional profiles from pre-vaccination peripheral blood predict immune response to preventative MUC1 cancer vaccine” and is a collaboration with Dr. Olja Finn, University of Pittsburgh.
In this paper, Daniel examines what molecular mechanisms pre-dispose someone to be responsive to a preventative cancer vaccine. This vaccine targets MUC1 protein which is elevated in colon cancer and it is administered to high-risk individuals. Analysis of single cell RNA-seq (scRNA-seq) data from blood collected pre-vaccination identified cell subpopulations and pathways that are characteristic of vaccine response, measured as IgG titers at week-12.
Another alumnus of the lab, Dr. Vineet Raghu, also contributed in this work.
Paper availability: [journal web site] [bioRxiv]
This is a great paper. Congratulations Daniel!
