Congratulations to our group member, Minxue Jia, for the acceptance of his first author paper in Molecular Systems Biology. His paper is entitled “LaGrACE: Estimating gene program dysregulation with latent regulatory network”.
In this study, Minxue presents a novel method for estimating disease-specific dysregulation of gene programs by combining omics data with clinical information. Haiyi Mao worked with Minxue in the development of this method.
LaGrACE first extracts latent factors that explain gene expression in a reference set of samples (controls) and then builds a causal graph with these latent factors and clinical data. The graph is used to group disease / treated samples by how much dysregulation each sample exhibits. The method was tested on multiple real-life datasets. One of the novel findings is that the LEF1 regulated genes are important for COPD mortality.
We are also grateful to Prof. Yu-Chih Chen and his student (Mengli Zhou) for collaborating in wet lab validation that we included in this study.
Paper availability: [journal web site]
Congratulations to Minxue and Haiyi!
